Why heart attacks cause so much more damage in late pregnancy

ScienceDaily (July 2, 2012) ? Heart attacks during pregnancy are uncommon, but the prevalence of heart disease in pregnant mothers has increased over the past decade as more women delay pregnancy until they are older. These women, who are generally less physically active than their younger peers, tend to have higher cholesterol levels and are at greater risk of heart disease and diabetes.

While research has shown that the heart typically functions better during pregnancy due to a rise in cardiac pumping capacity to meet increased demands, a new UCLA study in rats and mice demonstrates that heart attacks occurring in the last trimester or late months of pregnancy result in worse heart function and more damaged heart tissue than heart attacks among non-pregnant females.

The research is published in the July edition of the peer-reviewed journal Basic Research in Cardiology.

"This very early study may help us identify and better understand the mechanisms involved in the higher risks of heart disease during pregnancy and may provide new opportunities to better treat pregnant women with cardiovascular complications and risk factors," said senior study author Dr. Mansoureh Eghbali, an assistant professor of anesthesiology at the David Geffen School of Medicine at UCLA.

For the study, researchers assessed heart differences after heart attacks among late-stage pregnant female rats and non-pregnant animals. They found that the pregnant animals' hearts demonstrated poor functional recovery, with only 10 percent restoration of heart function, compared with 80 percent restoration among the non-pregnant group. The pregnant animals also had a four-fold increase in damaged heart tissue over the non-pregnant group.

"We observed worse heart function and a greater area of damage in hearts from the late-pregnancy group, compared to the non-pregnant group," said first author Dr. Jingyuan Li, a postdoctoral fellow in the department of anesthesiology at the Geffen School of Medicine.

"These findings show that the heart in late pregnancy may be particularly vulnerable to the type of injury caused by a heart attack," Eghbali said.

Surprisingly, one day after giving birth, the formerly pregnant animals' heart function was partially restored; after seven days, their heart function was almost fully restored to the levels of the corresponding non-pregnant state.

Researchers took a closer look to see what mechanisms were behind the heart's inability to effectively recover after such a cardiac event in late pregnancy.

After a heart attack -- caused by a lack of blood flow to the heart -- the reintroduction of blood to the affected area can sometimes lead to problems, a phenomenon known as reperfusion injury, they said. When the blood hits the oxygen-starved tissue, it can result in a sudden increase in oxygen radicals that cause cell damage.

The research team found that in late pregnancy, several components of this process are especially aggravated, including the dysfunction of mitochondria, which are key cellular sub-units that are involved in cell death, and the reduction of signaling proteins that protect the heart against reperfusion injury.

Eghbali noted that the next stages of research will focus on understanding in more detail why the heart in late pregnancy is at a higher risk for coronary heart disease and will explore interventions and identify promising candidates for drug therapy.

The study was funded by the National Institutes of Health (grants HL089876, HL089876S1, HL077440 and HL088975).

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The above story is reprinted from materials provided by University of California - Los Angeles Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jingyuan Li, Soban Umar, Andrea Iorga, Ji-Youn Youn, Yibin Wang, Vera Regitz-Zagrosek, Hua Cai, Mansoureh Eghbali. Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Research in Cardiology, 2012 DOI: 10.1007/s00395-012-0271-7

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120702162401.htm

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25 killed, 40 wounded in Baghdad market blast

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Source: http://news.yahoo.com/25-killed-40-wounded-baghdad-market-blast-092942036.html

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5 Best Goals at Euro 2012

By JOHN LEICESTER

AP Sports Columnist

Associated Press Sports

updated 10:20 a.m. ET July 1, 2012

KIEV, Ukraine (AP) - Heading into Sunday's European Championship final between Spain and Italy, 72 goals had been scored by the 16 teams that took part. Here's our pick of the top five (hoping, of course, that goals in the final might be even better):

---

DANNY WELBECK'S FLICK

The Manchester United forward scored only once for England at Euro 2012, but his goal was brilliant for its cunning and exquisite timing. With England and Sweden tied at 2 in the 78th minute of their June 15 group stage match, winger Theo Walcott sent in a cross. His back to the goal, Welbeck met the ball with his right leg and flicked it behind him with his heel, stunning Sweden goalkeeper Andreas Isaksson. A top-five selection because the 21-year-old Welbeck's execution was astounding and the goal secured the win for England.

---

ZLATAN IBRAHIMOVIC'S FAREWELL

Sweden was already eliminated when it played France on June 19 in Group D, but its towering frontman was determined to go out with a bang. With a roundhouse kick Bruce Lee would have been proud of, Ibrahimovic met Sebastian Larsson's cross and threw himself nearly sideways in the air to volley the ball with his right foot past Hugo Lloris.

---

SUBLIME DAVID SILVA

Controlling the ball 12 yards out, the nippy Spain midfielder faced a seemingly impenetrable wall of three Ireland defenders blocking his route to goal. So he improvised, dancing right then left before hitting the ball with pinpoint precision past one defender, through the legs of two others, and beyond goalkeeper Shay Given. It was Spain's second goal in a 4-0 Group C win on June 14. Laser-like.

---

SPAIN'S ONLY LAPSE

The same team Spain will face on Sunday, Italy, was also the only team that managed to score against the world and defending European champions at Euro 2012. Antonio Di Natale's chip past Iker Casillas in the 61st minute of their opening Group C match on June 10 wasn't the prettiest goal of Euro 2012, but it's a top five pick for its rarity.

---

COOL-HAND DUKES

Having the gall to softly chip a penalty over a diving goalkeeper, rather than firing to his left or right, is such the height of cool that this technique is named after its pioneer, Antonin Panenka. He used it to win the 1976 European Championship for Czechoslovakia against West Germany in a penalty shootout. At Euro 2012, Andrea Pirlo did it in Italy's quarterfinal shootout victory over England, and Sergio Ramos performed a "panenka" to help defending champion Spain beat Portugal in their semifinal penalty shootout. Brave.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Opinion: Balotelli challenging minds with his feet

KIEV, Ukraine (AP) - The ignoramus who scrawled "non sei un vero italiano, sei un africano nero'' - "You are not a true Italian, you are a black African'' - on a wall near the San Siro stadium in Milan. Did he, despite himself, leap off his sofa in delight when Mario Balotelli thumped home his goal for Italy with a powerful nod of his shaven black head and put their country into the final of Europe's top soccer tournament?

Source: http://nbcsports.msnbc.com/id/48031889/ns/sports-soccer/

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Source: http://news.yahoo.com/blogs/lookout/colorado-wildfires-waldo-canyon-fire-183708593.html

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Assembly OKs adding bank settlement into Calif law

FILE - In this June 22, 2012 file photo, DeAun Tollefson holds the notice of trustee sale, outside her home in Sacramento, Calif. California will become the first state to write into law much of the national mortgage settlement negotiated this year with the nation's top five banks, and expand it to all mortgages, if state lawmakers approve wide-ranging legislation on Monday, July 2, 2012.(AP Photo/Rich Pedroncelli, File)

FILE - In this June 22, 2012 file photo, DeAun Tollefson holds the notice of trustee sale, outside her home in Sacramento, Calif. California will become the first state to write into law much of the national mortgage settlement negotiated this year with the nation's top five banks, and expand it to all mortgages, if state lawmakers approve wide-ranging legislation on Monday, July 2, 2012.(AP Photo/Rich Pedroncelli, File)

SACRAMENTO, Calif. (AP) ? California will become the first state to write into law much of the national mortgage settlement negotiated this year with the nation's top five banks, and expand it to all mortgages, if state lawmakers approve wide-ranging legislation on Monday.

Majority Democrats say they have the votes to send the homeowner protection package to Gov. Jerry Brown despite opposition from business and lending organizations.

The Assembly approved the legislation on a 53-25 vote, and the Senate was preparing to take up the debate.

The legislation would require large lenders to provide a single point of contact for homeowners who want to discuss loan modifications. It would prohibit lenders from foreclosing while the lenders consider homeowners' request for alternatives to foreclosure. And it would let California homeowners sue lenders to stop foreclosures or seek monetary damages if the lender violates state law.

The protections would benefit all California homeowners, not just those whose mortgages are with the five banks that signed the national settlement in February. And many of the restrictions would become permanent, while those in the nationwide agreement will end after five years.

Jose Vega drove 70 miles to Sacramento with his two young children to lobby lawmakers to pass the legislation after he spent three years battling to keep his home in the San Francisco-area city of Pittsburg.

In November 2009, he said he found a trustee sale notice posted on his door 16 days after he was placed in a loan modification program. He was put into another modification program in the spring of 2010, only to have the bank again begin foreclosure proceedings.

Vega, 52, eventually kept his home after filing for bankruptcy and getting help from the office of Democratic U.S. Sen. Dianne Feinstein. Now he and his family owe $466,000 ? including the bank's legal fees ? on a home he said is worth about $200,000.

"I'm not asking for a handout. All I'm saying is, you created this mess, let's work something out," said Vega a member of the Alliance of Californians for Community Empowerment. "Hopefully, California will lead the way so other states will follow."

Attorney General Kamala Harris said the compromise legislation negotiated with lawmakers "is going to bring transparency and fairness to California homeowners in a way they've never had before."

She helped negotiate the February settlement that requires Bank of America Corp., JPMorgan Chase & Co., Wells Fargo & Co., Citigroup Inc. and Ally Financial Inc. to pay $18 billion in penalties to California homeowners.

Key portions of her original proposal to write the settlement into state law were stalled by opposition from some of her fellow Democrats in the Legislature, until the right to sue banks and other measures were significantly narrowed.

"This legislation can be the catalyst not only for a recovery of California's real estate market, but a catalyst across the nation as borrowers everywhere will demand the same protections given to California borrowers, the same protections given to our families," said Assemblyman Mike Feuer, D-Los Angeles, a member of the conference committee that negotiated the bill. "And those protections boil down to this: They ought to be treated fairly, they ought to be treated consistently."

Lenders' organizations joined by the California Chamber of Commerce said in a letter to lawmakers on Friday that the final legislation is an improvement, though they still fear it will "encourage frivolous litigation" by borrowers who cannot realistically afford to stay in their homes.

The lending industry cited a study it commissioned by Beacon Economics, a Los Angeles-based research firm. It echoes industry arguments that letting homeowners sue their lenders, even in limited circumstances, will delay foreclosures and increase lenders' costs, potentially harming the shaky housing recovery and making it more difficult and costly to obtain mortgages.

The legislation can't address what lenders say is the underlying problem: too many borrowers can't afford their payments.

"If we extend this, what we're doing is making a bad situation worse," Assemblywoman Diane Harkey, R-Dana Point, said in arguing against the bill.

Supporters of the bill say it still takes important steps.

"The point is ... not to launch an avalanche of lawsuits. What it's really about is having some meaningful accountability to ensure that servicers follow the rules," said Paul Leonard, director of the California office of the Center for Responsible Lending, a consumer group.

Previous efforts have repeatedly failed to clear the Legislature. Leonard said the national mortgage settlement and Harris' involvement are likely to make the difference this year.

Sen. Noreen Evans, D-Santa Rosa, who co-chaired the conference committee that negotiated the bill, said Brown's administration worked with Democrats on the legislation and has given every indication he would sign it into law. However, Brown declined to comment as he left the office of Senate President Pro Tem Darrell Steinberg, D-Sacramento, moments before the vote.

The law would not take effect until Jan. 1, though Evans and Harris said they expect lenders would begin following the new rules immediately even if the penalties don't yet apply.

____

Associated Press Writer Judy Lin contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-07-02-Foreclosures-California/id-24529d59d48e4ab28e7bde33ede5ad98

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Talkin' 'Bout Tablets: Scratching the Surface, Needing the Nexus 7

Well it was a news-filled week last week, what with Google I/O going on, and the buzz about all the announcements made there still hasn't died down. Tongues have been wagging here in the Linux blogosphere as well, but one little tidbit has drawn particular attention. That's the Android-powered Nexus 7, specifically, the prospect of which has more than a few geeks drooling with abandon.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/20ecabb8/l/0L0Stechnewsworld0N0Crsstory0C755280Bhtml/story01.htm

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Hey there

Hai there, frazzguy! Welcome to RolePlayGateway. :3 M'name's Sato, and I'm a longtime member around these parts. Nice to make your acquaintance, and whatnot.

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Don't worry about being too experienced, or not experienced. We come from all different walks of life and skill levels. The thing that sets RolePlayGateway apart from other websites is that we challenge you, and train you as well. We have an entire section of the website devoted to discussion roleplay theory, and offering tips and tricks from our members, to everyone else!

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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/XRWV6D3MIUM/viewtopic.php

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Japan whistleblower wins in Supreme Court

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Source: http://news.yahoo.com/japan-whistleblower-wins-supreme-court-044028006--finance.html

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